生物医药研发投入多、周期长、不确定性较大,这对于企业来说风险很高。针对生物医药研发、生产痛点,生物城配备了强大的专业外包服务。由魏于全院士领衔、成都高新区联合四川大学建设的生物医药国际平行实验室,建立了包括干细胞、细胞疫苗、CAR—T细胞、m RNA细胞等7大技术平台,拥有15条生产线,并对外开放共享,更以近乎成本价的费用为企业提供外包服务。
成都医学院的一位教授曾在平行实验室做了一个批次的临床实验,14天只花了5万元。而经过测算,该生产线14天的运行成本为4.9万元。
成都先导投资5亿元,在生物城孵化园建设了新药研发中心。成都先导建立了一个拥有自主知识产权的DNA编码化合物库筛选平台,能为企业新药研发提供“种子”,大幅缩短技术平台建立时间,降低筛选成本。目前平台中的化合物超过5000亿种,不久可达到万亿规模。
医药实验
Medical tests
威斯克生物
Westvac
Specialized outsourcing: Offering unlimited possibilities
The bio-town offers powerful specialized outsourcing services in light of the pain points in the R&D and production of biomedicine. The Biomedicine International Parallel Laboratory, led by Academ ician Wei Yuquan and jointly built by Chengdu High-Tech Industrial Development Zone and Sichuan University, has established seven technical platforms covering stem cells, cell vaccine, CAR-T cells and m RNA cells, as well as 15 production lines. This lab is also opened to the public, offering outsourcing services almost at cost prices to businesses. A professor at Chengdu Medical College once conducted a batch of clinical trials at this lab, which cost him only 50,000 yuan over a time span of 14 days. According to estimation, the production line the professor used ran at a cost of 49,000 yuan over a 14-day period.
HitGen, a Chengdu-based biotech company, invested 500 m illion yuan to build a new drug R&D center at the Incubation Park of the bio-town. HitGen has built a DNA-encoded compound library screening platform w ith independent intellectual property. The platform can provide the “seeds” of new drug development to businesses, which can substantially cut the time required for building technical platforms and reduce screening costs. To date, the platform has covered more than 500 billion compounds. This number w ill soon reach one trillion.
火石创造的企业业务全球服务中心与生物医药创新资源交易中心,瞄准企业在研发和市场营销的全流程,着力构建全球生物产业创新大数据服务平台及活动交易平台,实现专利、批件、临床成果的便捷交易。(www.xing528.com)
类似的新药创制技术创新大平台,还有华西海圻国家成都新药安全性评价中心、海枫生物临床前药物有效性评价平台、康诺行抗体药物中试生产基地、诺贝尔奖得主科恩伯格合作的创新型生物大分子药物的研发平台、诺峰全剂型国际制剂中心、泰格医药国际药物临床试验中心等。
如今,生物城内的专业外包服务已涵盖CRO、CMO/CDMO、CSO,分别服务于医药行业的研发、生产、销售三大环节。受益于创新产业链发展及政策驱动的影响,我国生物医药专业外包服务迎来增长的黄金时期。
The business-oriented Global Service Center and Biomedicine Innovation Resou rces Trading Center, built by Firestone, cover the whole business process from R&D to marketing. Firestone is comm itted to building a global bio-industry innovation big data service platform and an activity and trading platform that enable the easy trading of patents, approvals and clinical outcomes. Other sim ilar technical innovation platform s for new drug discovery(NDD) include West China-Frontier PharmaTech(WCFP) / National Chengdu Center for Safety Evaluation of Drugs(NCCSED), Haifeng Biotech’s Pre-clinical Drug Eff icacy Evaluation Platform, Kangnuoxing Biopharma’s Antibody Drug Pilot Production Base, the Innovative M acro-biomolecular Drugs R&D Platform in partnership w ith Roger D.Kornberg, Zennova’s International Preparation Center for a full range of formulations, and Tigermed’s International Drug Clinical Trial Center.
To date, the bio-tow n’s specialized outsourcing services have covered CROs, CMOs / CDMOs and CSOs w hich serve three m ajor processes of the pharmaceutical industry, i.e. research, manufacturing and sales.
安特金生物
Antejin Biotechnology
生产车间
Production workshop
天府疫苗谷
Tianfu Vaccine Valley
生物城展示中心
The exhibition center of Chengdu Tianfu InternationalBio-town
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